Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

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Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

The dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life…